disease-modifying
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New experiments clarify the role of SIRT1 in HD – or do they?
Work from multiple labs suggests activating a protein called SIRT1 might help HD, but the picture is still confusing
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Bone marrow transplantation in Huntington's Disease
Bone marrow transplant protects HD mice from some symptoms, suggesting the immune system may be an important target
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Melatonin treatment success in HD mice
Melatonin delays disease onset and extends survival in Huntington's disease mice ā could it do the same for patients?
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HDAC inhibitors and a possible 'blood biomarker'
HDAC inhibitors explained, plus how new HDAC-related Huntington's disease research might help us find biomarkers
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Gene silencing takes a targeted step forward
Targeting the mutant Huntington's disease gene for silencing, while leaving the healthy gene untouched
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Prana Biotech's new trial of PBT2 in Huntington's disease: the lowdown
Prana Biotech's PBT2 trial in Huntington's disease: what we know so far & what copper has to do with the mutant prote
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Protein-folding drug helps HD mice… for a while
A drug that activates an ancient cellular defense mechanism slows down HD in mice ā but why didnāt the benefit last?
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Re-routing the huntingtin protein inside cells
Canadian team decodes the tags that re-route the huntingtin protein within cells, helping explain how it becomes toxi
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KMO inhibitor drug improves lifespan of Huntington's disease mice
Positive results from tests of a new 'KMO inhibiting' drug in Huntington's disease mice
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Gene silencing for HD: the story so far
Is gene silencing as exciting as it sounds for HD, and what might the future hold?